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1-Phenethylamine → N-(1-naphthalen-1-ylethyl)-1-phenylethanamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Phenethylamine | HCID 7408 | — |
| 反応物 | 1-Acetylnaphthalene | HCID 13663 | — |
| 反応物 | Sodium cyanoborohydride | HCID 5003444 | — |
| 反応物 | (R)-N-(1-(4-methoxyphenyl)ethyl)-(R)-1-(1-naphthyl) ethylamine hydrochloride | HCID 69657690 | — |
| 触媒 | Titanium isopropoxide | HCID 11026 | — |
| 生成物 | N-(1-naphthalen-1-ylethyl)-1-phenylethanamine | HCID 22011087 | — |
反応手順
In a similar fashion equal molar amounts of (R))-1-phenylethylamine, 1′-acetonaphthone and 1.25 equivalents of titanium(IV) isopropoxide were mixed and the resulting intermediate imine was reduced with ethanolic sodium cyanoborohydride. Work-up and chromatography yielded N-[1-(1-naphthyl)ethyl)-1-phenylethylamine, 4G, as a clear, colorless oil; m/z (rel. int.) 275 (M+, 16), 260 (79), 155 (100), 127 (27), 105 (70), 77 (32).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06211244B1 |
| 出典データセット | uspto-grants-2001_04 |
| ORD ID | ord-5574b43b0c1941e8afe08e58d6314ea5 |
| 出典メモ | uspto-grants-2001_04 |