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1-Acetylnaphthalene → N-1-(1-naphthyl)ethyl-1-(3-methoxyphenyl)ethylamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Acetylnaphthalene | HCID 13663 | — |
| 反応物 | 1-(3-Methoxyphenyl)ethanamine | HCID 4612058 | — |
| 反応物 | Sodium cyanoborohydride | HCID 5003444 | — |
| 触媒 | Titanium isopropoxide | HCID 11026 | — |
| 生成物 | N-1-(1-naphthyl)ethyl-1-(3-methoxyphenyl)ethylamine | HCID 9796527 | — |
反応手順
In a similar fashion equal molar amounts of 1-(3-methoxyphenyl)ethylamine, 1′-acetonaphthone and 1.25 equivalents of titanium(IV) isopropoxide were mixed and the resulting intermediate imine was reduced with ethanolic sodium cyanoborohydride. Work-tip and chromatography yielded N-1-(1-naphthyl)ethyl-1-(3-methoxyphenyl)ethylamine, 6E, as a clear, colorless oil; m/z (rel. int.) 305 (M+, 10), 290 (30), 170 (43), 155 (100), 135 (69), 115 (9), 105 (15), 91 (14), 77 (18).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06211244B1 |
| 出典データセット | uspto-grants-2001_04 |
| ORD ID | ord-07505d6320414ed987b337d92c06d97a |
| 出典メモ | uspto-grants-2001_04 |