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Methylamine → 4-Nitro-(2-methylaminoethoxy)benzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methylamine | HCID 6329 | — |
| 反応物 | 1-(2-Chloroethoxy)-4-nitrobenzene | HCID 2764587 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 溶媒 | Sodium chloride; water | HCID 57417360 | — |
| 生成物 | 4-Nitro-(2-methylaminoethoxy)benzene | HCID 12294467 | — |
反応手順
A mixture of 4-nitro-(2-chloroethoxy)benzene (781 mg, 3.9 mmol) and aqueous methylamine (15 mL, 40 wt. %) in isopropyl alcohol (15 mL) is heated in a sealed tube at 100° for 4 hours. After cooling in an ice water bath, the mixtured is poured into brine and extracted 2× with dichloromethane, dried over sodium sulfate, filtered, and concentrated in vacuo to give 4-nitro-(2-methylaminoethoxy)benzene (697 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06211365B1 |
| 出典データセット | uspto-grants-2001_04 |
| ORD ID | ord-ab2a837b24004feb9e81f2c4770ebd7d |
| 出典メモ | uspto-grants-2001_04 |