2-(3,5-Dichlorophenyl)acetic acid → N-[(3,5-dichlorophenyl)acetyl]-L-alanine iso-butyl ester
反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([OH:12])=O)[CH:5]=[C:6]([Cl:8])[CH:7]=1.Cl.[CH2:14]([O:18][C:19](=[O:23])[C@H:20]([CH3:22])[NH2:21])[CH:15]([CH3:17])[CH3:16]>>[CH2:14]([O:18][C:19](=[O:23])[C@H:20]([CH3:22])[NH:21][C:10](=[O:12])[CH2:9][C:4]1[CH:5]=[C:6]([Cl:8])[CH:7]=[C:2]([Cl:1])[CH:3]=1)[CH:15]([CH3:17])[CH3:16]参加物
3
実験手順
Following General Procedure F′ above, and using 3,5-dichlorophenylacetic acid (from Example C′ above) and L-alanine iso-butyl ester hydrochloride (from Example B′ above), the title compound was prepared as a solid having a melting point of 115°-116° C. The reaction was monitored by tlc on silica gel (Rf=0.40 in 3% methanol/dichloromethane) and purification was by flash chromatography on silica gel using 3% methanol/dichloromethane as the eluant.
出典と根拠
- ORDレコード
- ord-b9cdb5d3ad6b4b9681142f7a004fcdad
- 出典データセット
- uspto-grants-2001_04
- 特許番号
- US06211235B1
反応ノート
読み込み中…