関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 4-Cyclohexylbenzoic acid | HCID 88337 | — |
| 反応物 | Diisobutylaluminumhydride | HCID 21225700 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | (4-Cyclohexylphenyl)methanol | HCID 22492024 | — |
反応手順
To a solution of 4cyclohexylbenzoic acid (Aldrich; 1 molar eq.) in toluene was added diisobutylaluminum hydride (Aldrich; 1 M in toluene; 4 molar eq.) over a 2 hour period. After addition was complete, the reaction was heated to 60° C. for 1 hour. The reaction was cooled to 5° C. and quenched with saturated aqueous ammonium chloride. The layers were separated and the aqueous layer extracted with ethyl acetate. The combined organics were filtered to remove salts and concentrated.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06211235B1 |
|---|
| 出典データセット | uspto-grants-2001_04 |
|---|
| ORD ID | ord-1ae4a04e146846a4ab1d12d37e57395c |
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| 出典メモ | uspto-grants-2001_04 |
|---|
