関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Valeryl chloride | HCID 61186 | — |
| 反応物 | 1-Aminocyclopentanecarbonitrile | HCID 2106897 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | N-(1-Cyanocyclopentyl)pentanamide | HCID 11790092 | — |
反応手順
To 11.0 g (0.1 mol) of 1-amino-1-cyanocyclopentane dissolved in 100 ml of dichloromethane, 15 ml 10. g (0.1 mol) of triethylamine was added, then dropwise 13 ml, 13 g (0.1 mol) of valeroyl chloride, while keeping the temperature at 25-35° C. The reaction mixture was stirred at 30-35° C. for 2 hours, then it was washed with water. The phases were separated, the organic phase was evaporated to obtain the pure title compound as an oil. The compound was identified by elementary analysis, IR, NMR and GC-MS spectrometry.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06211382B1 |
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| 出典データセット | uspto-grants-2001_04 |
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| ORD ID | ord-c955579b5894498eafbf043d733950c1 |
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| 出典メモ | uspto-grants-2001_04 |
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