化工社化工社 化学情報印刷レポート · 研究参考用
Methanol → Salicylic acid, 4-nitro-, methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Toluene | HCID 1140 | — |
| 反応物 | 4-Nitrosalicylic acid | HCID 69266 | — |
| 反応物 | Trimethylsilyldiazomethane | HCID 167693 | — |
| 溶媒 | Hexane | HCID 8058 | — |
| 生成物 | Salicylic acid, 4-nitro-, methyl ester | HCID 139539 | 100% |
反応手順
916 mg (5 mmol) of 2-hydroxy-4-nitro-benzoic acid is dissolved in a mixture that consists of 8 ml of methanol and 32 ml of toluene, and it is slowly mixed with a solution of trimethylsilyldiazomethane in hexane (2 molar). After the addition is completed, stirring is continued for 1.25 hours at room temperature. After the reaction mixture is concentrated by evaporation, 1 g (about 100% of theory) of 2-hydroxy-4-nitro-benzoic acid methyl ester is obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07427390B2 |
| 出典データセット | uspto-grants-2008_09 |
| ORD ID | ord-f4482a156b1b490eac5d912bb108e093 |
| 出典メモ | uspto-grants-2008_09 |