関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Iodide | HCID 4875 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 4'-Benzyloxy-2'-hydroxyacetophenone | HCID 309257 | — |
| 反応物 | Ethyl 4-chloro-4-phenylbutanoate | HCID 12847348 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | ethyl (RS)-4-(2-acetyl-5-benzyloxy-phenoxy)-4-phenylbutanoate | HCID 23204307 | 34.1% |
反応手順
A mixture of 4-benzyloxy-2-hydroxyaceto-phenone (1.2 g), ethyl (RS)-4-chloro-4-phenyl-butanoate (1.21 g), potassium carbonate (760 mg), potassium iodide (35 mg) and dimethylformamide (30 mL) is stirred at 100° C. for 8 hours. It is evaporated to dryness and the resulting residue is partitioned between ethyl acetate (200 mL) and water (200 mL). The organic layer is dried over magnesium sulphate, filtered and concentrated in vacuo. Flash chromatography of the resulting oil, eluting with 15-30% ethyl acetate/hexane, affords ethyl (RS)-4-(2-acetyl-5-benzyloxy-phenoxy)-4-phenylbutanoate (0.73 g), in the form of a yellow oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US06211234B1 |
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| 出典データセット | uspto-grants-2001_04 |
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| ORD ID | ord-38a7180b845244e4becca23853d94f6e |
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| 出典メモ | uspto-grants-2001_04 |
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