1-Isocyanato-2-phenylbenzene → N-(2-hydroxy-4-trifluoromethylphenyl) N'-(2-phenylphenyl)urea

HRID 323047

反応式

HRID 323047 の反応式
[OH:1][C:2]1[CH:8]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:6]=[CH:5][C:3]=1[NH2:4].[C:13]1([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[N:25]=[C:26]=[O:27])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[OH:1][C:2]1[CH:8]=[C:7]([C:9]([F:10])([F:11])[F:12])[CH:6]=[CH:5][C:3]=1[NH:4][C:26]([NH:25][C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=1[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:27]

参加物

3

反応物 2

HCID 2222801-Isocyanato-2-phenylbenzeneHCID 155242772-Amino-5-(trifluoromethyl)phenol

生成物 1

HCID 22011313N-(2-hydroxy-4-trifluoromethylphenyl) N'-(2-phenylphenyl)urea収率 64%

実験手順

The urea was prepared from 2-hydroxy 4-trifluoromethyl aniline (example 7a, 0.171 g, 1 mmol)) and 2-phenyl phenyl isocyanate by general Method B. It was purified by dilution with methylene chloride and precipitation with hexane. Filtering afforded the desired compound (0.24 g, 64%). EI-MS m/z 373 (M+H)+

後処理

  1. customIt was purified by dilution with methylene chloride and precipitation with hexane
  2. filtrationFiltering

出典と根拠

ORDレコード
ord-7e23817612054b48a855d8005ac8aff3
出典データセット
uspto-grants-2001_04
特許番号
US06211373B1

関連ノート

読み込み中…