Hydrochloric Acid → N-Phenyl-3-piperidinecarboxamide hydrochloride

反応式

C(OC([N:8]1[CH2:13][CH2:12][CH2:11][CH:10]([C:14]([NH:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[O:15])[CH2:9]1)=O)(C)(C)C.[ClH:23]>>[ClH:23].[NH:8]1[CH2:13][CH2:12][CH2:11][CH:10]([C:14]([NH:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[O:15])[CH2:9]1

参加物

反応物 2

HCID 313Hydrochloric Acid

HCID 181042161,1-Dimethylethyl 3-[(phenylamino)carbonyl]-1-piperidinecarboxylate

生成物 1

HCID 16303570N-Phenyl-3-piperidinecarboxamide hydrochloride収率 55%

実験手順

A solution of 1-t-butoxycarbonyl-3-piperidinecarboxanilide (437 mg, 1.43 mmol) and hydrochloride (1 ml, 4.00 mmol, 4N ethyl acetate) was stirred for several hours. Filtration of the precipitate gave 3-piperidinecarboxanilide hydrochloride (187 mg, 55%).

後処理

filtrationFiltration of the precipitate

出典と根拠

ORDレコード: ord-00c3107a1e1b4b18a692d37fb34de1d3
出典データセット: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07427615B2

反応ノート

読み込み中…

参加物