Piperazine → HCID 22010937、化合物

HRID 323137ノート

反応式

HRID 323137 の反応式
[N+:1]([C:4]1[CH:33]=[CH:32][C:7]([C:8]([N:10]([CH3:31])[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[O:17][CH2:18][CH2:19][CH2:20][NH:21][C:22]([O:24]C2C=CC=CC=2)=O)=[O:9])=[CH:6][CH:5]=1)([O-:3])=[O:2].[NH:34]1[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]1.[CH3:40]N(C)C=O>C(OCC)(=O)C>[N+:1]([C:4]1[CH:33]=[CH:32][C:7]([C:8]([N:10]([CH3:31])[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[O:17][CH2:18][CH2:19][CH2:20][NH:21][C:22]([N:34]2[CH2:39][CH2:38][N:37]([CH3:40])[CH2:36][CH2:35]2)=[O:24])=[O:9])=[CH:6][CH:5]=1)([O-:3])=[O:2]

参加物

5

反応物 3

HCID 4837PiperazineHCID 6228DimethylformamideHCID 220105644-nitro-N-methyl-N-[2-(3-phenoxycarbonylaminoprop-1-yloxy)phenyl]benzamide

生成物 1

HCID 22010937HCID 22010937、化合物

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

反応条件

温度
80 °C

実験手順

A mixture of 4-nitro-N-methyl-N-[2-(3-phenoxycarbonylaminoprop-1-yloxy)phenyl]benzamide (383 mg) and piperazine (256 mg) in N,N-dimethylformamide (8 ml) was stirred at 80° C. for 3 hours. The reaction mixture was diluted with ethyl acetate and then the organic solution was washed successively with saturated sodium bicarbonate aqueous solution and brine. Drying, filtering and removal of solvents afforded 4-nitro-N-methyl-N-[2-{3-(4-methyl-1-piperazinyl)carbonylaminoprop-1-yloxy}phenyl]benzamide (357 mg) as a slightly yellow oil.

後処理

  1. washthe organic solution was washed successively with saturated sodium bicarbonate aqueous solution and brine
  2. customDrying
  3. filtrationfiltering
  4. customremoval of solvents

出典と根拠

ORDレコード
ord-a3d31a6965364de9a8b4ed9347b47f78
出典データセット
uspto-grants-2001_04
特許番号
US06211242B1

反応ノート

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