Potassium Carbonate → HCID 22010926、化合物

HRID 323167ノート

反応式

HRID 323167 の反応式
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]([C:14]([NH:16][C:17]3[CH:39]=[CH:38][C:20]([C:21]([N:23]([CH3:37])[C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=4[O:30][CH2:31][CH2:32][O:33]C(=O)C)=[O:22])=[CH:19][CH:18]=3)=[O:15])=[CH:10][CH:11]=[CH:12][CH:13]=2)=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+]>CO.C(OCC)(=O)C>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:9]([C:14]([NH:16][C:17]3[CH:18]=[CH:19][C:20]([C:21]([N:23]([CH3:37])[C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=4[O:30][CH2:31][CH2:32][OH:33])=[O:22])=[CH:38][CH:39]=3)=[O:15])=[CH:10][CH:11]=[CH:12][CH:13]=2)=[CH:6][CH:7]=1

参加物

5

反応物 2

HCID 11430Potassium CarbonateHCID 22010642HCID 22010642、化合物

生成物 1

HCID 22010926HCID 22010926、化合物

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 8857Ethyl Acetate溶媒

実験手順

A mixture of 4-(4′-methylbiphenyl-2-carboxamido)-N-methyl-N-[2-(2-acetoxyethoxy)phenyl]benzamide and potassium carbonate (129 mg) in methanol (15 ml) was stirred at ambient temperature for 2 hours and the mixture was diluted with ethyl acetate (30 ml). The solution was washed with water and brine and the organic solution was dried over magnesium sulfate and the solvent was evaporated in vacuo to give 4-(4′-methylbiphenyl-2-carboxamido)-N-methyl-N-[2-(2-hydroxyethoxy)phenyl]benzamide (450 mg) as an oil.

後処理

  1. washThe solution was washed with water and brine
  2. dry with materialthe organic solution was dried over magnesium sulfate
  3. customthe solvent was evaporated in vacuo

出典と根拠

ORDレコード
ord-f6f2868a7619450d80804b138a0c7720
出典データセット
uspto-grants-2001_04
特許番号
US06211242B1

反応ノート

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