Methanesulfonic Acid → 1-(3,4,5-Trimethoxybenzoyl)-3-(2-(4-(1-(2-ethoxyethyl)-1h-benzimidazol-2-yl-amino)piperidin-1-yl)ethyl)-3-(3,4-dimethylphenyl)pyrrolidine methanesulfonic acid salt

HRID 323231

反応式

HRID 323231 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:44]=[C:45]([O:49][CH3:50])[C:46]=1[O:47][CH3:48])[C:6]([N:8]1[CH2:12][CH2:11][C:10]([CH2:21][CH2:22][N:23]2[CH2:28][CH2:27][CH:26]([NH:29][C:30]3[N:34]([CH2:35][CH2:36][O:37][CH2:38][CH3:39])[C:33]4[CH:40]=[CH:41][CH:42]=[CH:43][C:32]=4[N:31]=3)[CH2:25][CH2:24]2)([C:13]2[CH:18]=[CH:17][C:16]([CH3:19])=[C:15]([CH3:20])[CH:14]=2)[CH2:9]1)=[O:7].[CH3:51][S:52]([OH:55])(=[O:54])=[O:53]>>[CH3:51][S:52]([OH:55])(=[O:54])=[O:53].[CH3:50][O:49][C:45]1[CH:44]=[C:5]([CH:4]=[C:3]([O:2][CH3:1])[C:46]=1[O:47][CH3:48])[C:6]([N:8]1[CH2:12][CH2:11][C:10]([CH2:21][CH2:22][N:23]2[CH2:24][CH2:25][CH:26]([NH:29][C:30]3[N:34]([CH2:35][CH2:36][O:37][CH2:38][CH3:39])[C:33]4[CH:40]=[CH:41][CH:42]=[CH:43][C:32]=4[N:31]=3)[CH2:27][CH2:28]2)([C:13]2[CH:18]=[CH:17][C:16]([CH3:19])=[C:15]([CH3:20])[CH:14]=2)[CH2:9]1)=[O:7]

参加物

3

反応物 2

HCID 6395Methanesulfonic AcidHCID 98313851-(3,4,5-trimethoxybenzoyl)-3-(2-(4-(1-(2-ethoxyethyl)-1H-benzimidazol-2-yl-amino)piperidin-1-yl)ethyl)-3-(3,4-dimethylphenyl)pyrrolidine

生成物 1

HCID 220091151-(3,4,5-Trimethoxybenzoyl)-3-(2-(4-(1-(2-ethoxyethyl)-1h-benzimidazol-2-yl-amino)piperidin-1-yl)ethyl)-3-(3,4-dimethylphenyl)pyrrolidine methanesulfonic acid salt

実験手順

Prepare by the method of Example 3.7 using 1-(3,4,5-trimethoxybenzoyl)-3-(2-(4-(1-(2-ethoxyethyl)-1H-benzimidazol-2-yl-amino)piperidin-1-yl)ethyl)-3-(3,4-dimethylphenyl)pyrrolidine (0.4 g, 0.61 mmol) and methanesulfonic acid (0.24 g) to give the title compound: mp; 87-97° C.

出典と根拠

ORDレコード
ord-c605c6adbb984fb896c08fd23f12a034
出典データセット
uspto-grants-2001_04
特許番号
US06211199B1

関連ノート

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