1-Benzyl-3-(phenylmethyl)-3-(2-hydroxyethyl)pyrrolidine → HCID 18464730、化合物
反応式
C([N:8]1[CH2:12][CH2:11][C:10]([CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)([CH2:13][CH2:14][OH:15])[CH2:9]1)C1C=CC=CC=1>O.[Pd].CO>[C:17]1([CH2:16][C:10]2([CH2:13][CH2:14][OH:15])[CH2:11][CH2:12][NH:8][CH2:9]2)[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1参加物
4
実験手順
Combine 1-benzyl-3-(phenylmethyl)-3-(2-hydroxyethyl)pyrrolidine (0.72 g, 2.45 mmol) and methanol (20 mL). Add 20% palladium hydroxide-on-carbon (0.231 g). Hydrogenate in a Parr apparatus at an initial pressure of 50 psi. After 24 hours, filter through celite, rinse with methanol. Evaporate the filtrate in vacuo to give the title compound: Rf=0.01 (silica gel, 2% triethylamine/methanol).
後処理
- filtrationfilter through celite
- washrinse with methanol
- customEvaporate the filtrate in vacuo
出典と根拠
- ORDレコード
- ord-6415242d822a40c1bc5e538e70b6350a
- 出典データセット
- uspto-grants-2001_04
- 特許番号
- US06211199B1
反応ノート
読み込み中…