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HRID 323317作成日：2026年10月26日

Ammonium formate → 1-(3,4,5-trimethoxybenzoyl)-3-(2-(4-(1-(1H-imidazol-2-ylmethyl)-1H-benzimidazol-2-yl-amino)piperidin-1-yl)ethyl)-3-(3,4-difluorophenyl) pyrrolidine

https://huagongshe.com/reaction/323317

反応式

関与物質

役割名称HCID仕込み量
反応物Ammonium formateHCID 2723923—
反応物1-(3,4,5-trimethoxybenzoyl)-3-(2-(4-(1-(1-benzyl-1H-imidazol-2-ylmethyl)-1H-benzimidazol-2-yl-amino)piperidin-1-yl)ethyl)-3-(3,4-difluorophenyl) pyrrolidineHCID 69955259—
触媒PalladiumHCID 23938—
溶媒MethanolHCID 887—
生成物1-(3,4,5-trimethoxybenzoyl)-3-(2-(4-(1-(1H-imidazol-2-ylmethyl)-1H-benzimidazol-2-yl-amino)piperidin-1-yl)ethyl)-3-(3,4-difluorophenyl) pyrrolidineHCID 20642283—

反応手順

Combine 1-(3,4,5-trimethoxybenzoyl)-3-(2-(4-(1-(1-benzyl-1H-imidazol-2-ylmethyl)-1H-benzimidazol-2-yl-amino)piperidin-1-yl)ethyl)-3-(3,4-difluorophenyl) pyrrolidine (5 mmol) and 10% palladium-on-carbon (1.5 g) in methanol (50 mL). Add anhydrous ammonium formate (25 mmol). Heat to reflux. After 18 hours, filter, rinse with dichloromethane, and evaporate the filtrate in vacuo to give the title compound.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US06211199B1
出典データセットuspto-grants-2001_04
ORD IDord-87aa56e966bd4303b7547e00eb71c990
出典メモuspto-grants-2001_04