化工社化工社 化学情報印刷レポート · 研究参考用
Dichloromethane → (1-(4-Oxopentyl)-1H-benzimidazol-2-yl)(piperidin-4-yl)amine Hydriodic Acid Salt
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dichloromethane | HCID 6344 | — |
| 反応物 | Hydrogen iodide | HCID 24841 | — |
| 反応物 | (1-(4-oxopentyl)-1H-benzimidazol-2-yl)(1-(t-butoxycarbonyl)piperidin-4-yl)amine | HCID 22009233 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | (1-(4-Oxopentyl)-1H-benzimidazol-2-yl)(piperidin-4-yl)amine Hydriodic Acid Salt | HCID 86756597 | — |
反応手順
Combine (1-(4-oxopentyl)-1H-benzimidazol-2-yl)(1-(t-butoxycarbonyl)piperidin-4-yl)amine, ethylene ketal (0.9 g, 2.0 mmol) and dichloromethane (20 mL). Cool in an ice bath and add hydriodic acid (0.53 mL, 57%, 4.05 mmol). Warm to ambient temperature. After 0.5 hours, add water (0.5 mL) and heat to reflux. After 18 hours, cool to ambient temperature and evaporate in vacuo to give the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06211199B1 |
| 出典データセット | uspto-grants-2001_04 |
| ORD ID | ord-70c33d0dc40746d3859726d21fe62f3e |
| 出典メモ | uspto-grants-2001_04 |