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HRID 323347作成日：2026年10月26日

3,4,5-Trimethoxybenzoyl-3-phenyl-3-(2-methanesulfonyloxyethyl)pyrrolidine → 1-(3,4,5-trimethoxybenzoyl)-3-(2-(4-(1-(4-oxopentyl)-1H-benzimidazol-2-yl-amino)piperidin-1-yl)ethyl)-3-phenylpyrrolidine

https://huagongshe.com/reaction/323347

反応式

関与物質

役割名称HCID仕込み量
反応物3,4,5-Trimethoxybenzoyl-3-phenyl-3-(2-methanesulfonyloxyethyl)pyrrolidineHCID 18464630—
反応物(1-(4-Oxopentyl)-1H-benzimidazol-2-yl)(piperidin-4-yl)amine Hydriodic Acid SaltHCID 86756597—
生成物1-(3,4,5-trimethoxybenzoyl)-3-(2-(4-(1-(4-oxopentyl)-1H-benzimidazol-2-yl-amino)piperidin-1-yl)ethyl)-3-phenylpyrrolidineHCID 20642297—

反応手順

Prepare by the method of Example 1.6 using 1-(3,4,5-trimethoxybenzoyl)-3-phenyl-3-(2-methanesulfonyloxyethyl)pyrrolidine (prepared from (−)-3-phenyl-3-(2-hydroxyethyl)pyrrolidine (R,R)-di-p-anisoyltartaric acid salt) and (1-(4-oxopentyl)-1H-benzimidazol-2-yl)(piperidin-4-yl)amine hydriodic acid salt to give the title compound.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US06211199B1
出典データセットuspto-grants-2001_04
ORD IDord-33c96756594a48d8bf9d375bc2f4b4a1
出典メモuspto-grants-2001_04