化工社化工社 化学情報印刷レポート · 研究参考用
4-Methylmorpholine → Boc-Leu-Glu-OtBu
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Methylmorpholine | HCID 7972 | — |
| 反応物 | 1-(1,1-Dimethylethyl) hydrogen L-glutamate | HCID 117505 | — |
| 反応物 | Boc-Leu-OSu | HCID 11023929 | — |
| 触媒 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | Boc-Leu-Glu-OtBu | HCID 87984260 | — |
反応手順
To a solution of Boc-Leu-OSu and Glu-OtBu in DMF was added NMM and DMAP. The solution was stirred at ambient temperatures for 18 hours then the solvent was removed. Crude product was taken up in 100 ml CHCl3, washed 3× with pH 3 water (100 ml), once with water (100 ml) and once with brine (100 ml). Organic layer was dried with MgSO4 and filtered. Solvent was removed and solid was dried over vacuum. Solid was collected as a white powder (8.78 g, quant. yield, ˜80% purity TLC). Product was used directly without further characterization.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07427600B2 |
| 出典データセット | uspto-grants-2008_09 |
| ORD ID | ord-a4465bcbca00476b927678186da410d5 |
| 出典メモ | uspto-grants-2008_09 |