Potassium Hydroxide → 5-Mesyl-o-anisic acid

HRID 323395ノート

反応式

HRID 323395 の反応式
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]([S:13]([CH3:16])(=[O:15])=[O:14])=[CH:9][C:4]=1[C:5]([O:7]C)=[O:6].[OH-].[K+]>>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]([S:13]([CH3:16])(=[O:15])=[O:14])=[CH:9][C:4]=1[C:5]([OH:7])=[O:6]

参加物

3

反応物 2

HCID 14797Potassium HydroxideHCID 6454622Methyl 5-mesyl-o-anisate

生成物 1

HCID 1708405-Mesyl-o-anisic acid

実験手順

Combine methyl 2-methoxy-5-methylsulfonylbenzoate (2.24 g, 9.2 mmol) and a 1 M aqueous potassium hydroxide solution (10 mL, 10 mmol). Heat to reflux. After 2 hours, filter while still hot, cool in an ice bath, and acidify by dropwise addition of a 1 M aqueous hydrochloric acid solution (11 mL) to give a solid. Collect the solid by filtration, rinse with water, and dry to give the title compound.

後処理

  1. temperatureHeat to reflux
  2. filtrationfilter while still hot,
  3. temperaturecool in an ice bath
  4. additionacidify by dropwise addition of a 1 M aqueous hydrochloric acid solution (11 mL)
  5. customto give a solid
  6. customCollect the solid
  7. filtrationby filtration
  8. washrinse with water
  9. customdry

出典と根拠

ORDレコード
ord-51e6a8f6e2ec4f5b836d67b9f2ad5d02
出典データセット
uspto-grants-2001_04
特許番号
US06211199B1

反応ノート

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