化工社化工社 化学情報印刷レポート · 研究参考用
Sodium Azide → 3-Azido-1-benzhydrylazetidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Azide | HCID 33557 | — |
| 反応物 | 1-Benzhydrylazetidin-3-yl 4-methylbenzenesulfonate | HCID 15512651 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 3-Azido-1-benzhydrylazetidine | HCID 15512652 | — |
反応手順
A solution of 9 (11.5 g, 31.8 mmol) and sodium azide (4.12 g, 64 mmol) in 250 ml of DMF was heated to 70° C. for 24 hours. After cooling to room temperature the solvent was removed in vacuo and the residue partitioned between chloroform and water. The organics were dried over MgSO4, filtered and the solvent removed in vacuo. The crude product was purified by chromatography on silica gel (8:1 hexane: ethyl acetate) afforded the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06214832B1 |
| 出典データセット | uspto-grants-2001_04 |
| ORD ID | ord-b1217393730944209c1603dc36d443ea |
| 出典メモ | uspto-grants-2001_04 |