Hydrochloric Acid → HCID 15523743、化合物

反応式

Cl[S:2]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][C:9](=[O:14])[C:8]2([Cl:16])[Cl:15])(=[O:4])=[O:3].[CH2:17]([NH2:24])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.Cl>C(Cl)Cl>[CH2:17]([NH:24][S:2]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][C:9](=[O:14])[C:8]2([Cl:16])[Cl:15])(=[O:4])=[O:3])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

参加物

実験手順

To a solution of 5-chlorosulfonyl-3,3-dichloro-2-oxindole (100 mg, 400 umol) in methylene chloride (3 mL) was added benzylamine (135 uL, 1.2 mmol) dropwise. After stirring for 4 h. 3 N hydrochloric acid was added along with an additional volume of methylene chloride (20 mL). The organic layer was dried over magnesium sulfate, filtered, and silica gel flash chromatography (25 to 35% ethyl acetate/hexanes) yielded the title compound. ES (−) MS m/e=369 (M−H).