Enprofylline → 7-Benzyl-3-propylxanthine

関与物質

反応条件

反応手順

4.12 g (0.103 mol) of sodium hydroxide dissolved in 41 ml of water were added to a suspension of 20 g (0.103 mol) of 3-propylxanthine in 112 ml of methanol and the reaction mixture was stirred at 70° C. for one hour, then treated dropwise at the same temperature with 12.23 ml (0.103 mol) of benzyl bromide and kept between 70° and 80° C. for 4 hours. The mixture was cooled, filtered cold on a suction filter, and the product was washed with water on the suction filter and dried under reduced pressure.

情報源と証拠