Sodium Bicarbonate → (RS)-Clopidogrel

HRID 323894

反応式

HRID 323894 の反応式
C12(CS(O)(=O)=O)C(C)(C)C(CC1)CC2=O.[CH3:16][O:17][C:18](=[O:36])[CH:19]([C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=1[Cl:35])[N:20]1[CH2:25][CH2:24][C:23]2[S:26][CH:27]=[CH:28][C:22]=2[CH2:21]1.C(=O)([O-])O.[Na+]>ClCCl>[CH3:16][O:17][C:18](=[O:36])[CH:19]([C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=1[Cl:35])[N:20]1[CH2:25][CH2:24][C:23]2[S:26][CH:27]=[CH:28][C:22]=2[CH2:21]1

参加物

4

反応物 2

HCID 516892Sodium BicarbonateHCID 156143992-chlorophenyl(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetic acid methyl ester (-)-camphorsulfonic acid salt

生成物 1

HCID 2806(RS)-Clopidogrel

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To the suspension made of 200 g of (+)-(2-chlorophenyl)(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetic acid methyl ester (−)-camphorsulfonic acid salt and 800 ml of dichloromethane is added 800 ml of sodium hydrogen carbonate solution. After stirring the organic phase is separated by decantation, dried on sodium sulfate and the solvent is removed in vacuo. The (+)-(2-chlorophenyl)(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetic acid methyl ester is obtained as a solution in 800 ml of dichloromethane. After stirring, the organic phase is separated by decantation, dried over sodium sulfate and the solvent is removed in vacuo.

後処理

  1. customis separated by decantation
  2. customdried on sodium sulfate
  3. customthe solvent is removed in vacuo

出典と根拠

ORDレコード
ord-93f39ecc13554fcdb3469ca7282d9e22
出典データセット
uspto-grants-2001_04
特許番号
US06215005B1

関連ノート

読み込み中…