化工社化工社 化学情報印刷レポート · 研究参考用
Chloroacetone → (p-Tolylsulphonyl)acetone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Chloroacetone | HCID 6571 | — |
| 反応物 | Sodium toluene-4-sulphinate dihydrate | HCID 23678556 | — |
| 反応物 | Water benzene acetone | HCID 68819625 | — |
| 溶媒 | Ethylacetate heptane | HCID 21899848 | — |
| 生成物 | (p-Tolylsulphonyl)acetone | HCID 79327 | 95% |
反応手順
Was prepared according to Crandall et al. J. Org. Chem. 1985, (8) 50, 1327-1329 from sodium p-toluensulfinate dihydrate (4.2 g, 18 mmol), chloroacetone (1.0 mL, 12 mmol), n-tetrabutylammonium bromide (0.30 g) and water-benzene-acetone 4:3:3 (10 mL). Work-up and chromatography on silica of the crude using ethyl acetate/n-heptane (1:3 through 1:2) as eluent gave 2.4 g (95%) of the title product as an oil which crystallised on standing in the fridge.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07427631B2 |
| 出典データセット | uspto-grants-2008_09 |
| ORD ID | ord-f7c0cf0c691042ad8dc440d4807c84dd |
| 出典メモ | uspto-grants-2008_09 |