Phenol → N-(1,1-dimethyl-2-phenoxyethyl)acetamide

HRID 323981

反応式

HRID 323981 の反応式
[C:1]1([OH:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:8][C:9]1[O:10][CH2:11][C:12]([CH3:15])([CH3:14])[N:13]=1>C(OCC)(=O)C>[CH3:11][C:12]([NH:13][C:9](=[O:10])[CH3:8])([CH3:15])[CH2:14][O:7][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

4

反応物 2

HCID 996PhenolHCID 744964,5-Dihydro-2,4,4-trimethyloxazole

生成物 1

HCID 18349669N-(1,1-dimethyl-2-phenoxyethyl)acetamide

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

反応条件

温度
220 °C

実験手順

A mixture of phenol (33.2 g) and 2,4,4-trimethyloxazoline (18.1 g) was heated in a stirred pressure vessel at 220° C. for 48 hours. The oil obtained on cooling was dissolved in ethyl acetate, washed with 5M sodium hydroxide solution, water, brine, then dried and evaporated to give an oil which was distilled under high vacuum to give N-(1,1-dimethyl-2-phenoxyethyl)acetamide, b.p. 115-122° C. at 0.67 mbar.

後処理

  1. customThe oil obtained
  2. temperatureon cooling
  3. washwashed with 5M sodium hydroxide solution, water, brine
  4. customdried
  5. customevaporated
  6. customto give an oil which
  7. distillationwas distilled under high vacuum

出典と根拠

ORDレコード
ord-1749e9a681eb441b84dcb70966c475f7
出典データセット
uspto-grants-2001_04
特許番号
US06215001B1

関連ノート

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