化工社化工社 化学情報印刷レポート · 研究参考用
1H-indole-6-carboxylic acid → 4-{2-(1H-Indole-6-carbonyl)amino-2-(2-chlorophenyl)ethoxy-methyl}piperidine-1-carboxylic acid tert-butyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1H-indole-6-carboxylic acid | HCID 595230 | — |
| 反応物 | 4-[2-Amino-2-(2-chlorophenyl)-ethoxymethyl]piperidine-1-carboxylic acid tert-butyl ester | HCID 69309645 | — |
| 生成物 | 4-{2-(1H-Indole-6-carbonyl)amino-2-(2-chlorophenyl)ethoxy-methyl}piperidine-1-carboxylic acid tert-butyl ester | HCID 69310546 | — |
反応手順
Using coupling method A, 4-[2-amino-2-(2-chlorophenyl)-ethoxymethyl]piperidine-1-carboxylic acid tert-butyl ester (500 mg, 1.4 mmol) and indole-6-carboxylic acid (219 mg, 1.4 mmol) afforded, after purification (SiO2: 33% to 50% EtOAc in hexane), 579 mg (83%) of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07427632B2 |
| 出典データセット | uspto-grants-2008_09 |
| ORD ID | ord-525fbdd5965f4adf81119bc7dd4580df |
| 出典メモ | uspto-grants-2008_09 |