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6-Chloro-1-benzothiophene-2-carboxylic acid → 4-{2-[(6-Chlorobenzo[b]thiophene-2-carbonyl)amino]-2-(2-chlorophenyl)ethoxymethyl}piperidine-1-carboxylic acid tert-butyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 6-Chloro-1-benzothiophene-2-carboxylic acid | HCID 7141919 | — |
| 反応物 | 4-[2-Amino-2-(2-chlorophenyl)-ethoxymethyl]piperidine-1-carboxylic acid tert-butyl ester | HCID 69309645 | — |
| 生成物 | 4-{2-[(6-Chlorobenzo[b]thiophene-2-carbonyl)amino]-2-(2-chlorophenyl)ethoxymethyl}piperidine-1-carboxylic acid tert-butyl ester | HCID 69310562 | — |
反応手順
Using coupling method A, 4-[2-amino-2-(2-chlorophenyl)-ethoxymethyl]piperidine-1-carboxylic acid tert-butyl ester (300 mg, 0.8 mmol) and 6-chlorobenzo[b]thiophene-2-carboxylic acid (172 mg, 0.8 mmol) afforded, after purification (SiO2: 50% EtOAc in hexane), 353 mg (77%) of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07427632B2 |
| 出典データセット | uspto-grants-2008_09 |
| ORD ID | ord-d35e5ad97cae48f3be814ab7807cbfc6 |
| 出典メモ | uspto-grants-2008_09 |