Anisole → HCID 9866338、化合物
反応式
C1(OC)C=CC=CC=1.C(OC([N:16]1[CH2:21][CH2:20][CH:19]([CH2:22][O:23][CH2:24][C@H:25]([NH:32][C:33]([C:35]2[CH:43]=[C:42]3[C:38]([C:39]([Cl:44])=[CH:40][NH:41]3)=[CH:37][CH:36]=2)=[O:34])[C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH2:18][CH2:17]1)=O)(C)(C)C>>[Cl:44][C:39]1[C:38]2[C:42](=[CH:43][C:35]([C:33]([NH:32][C@H:25]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[CH2:24][O:23][CH2:22][CH:19]3[CH2:18][CH2:17][NH:16][CH2:21][CH2:20]3)=[O:34])=[CH:36][CH:37]=2)[NH:41][CH:40]=1参加物
3
実験手順
Using deprotection method B, but without addition of anisole, 4-{(R)-2-[(3-chloro-1H-indole-6-carbonyl)amino]-2-phenylethoxymethyl}piperidine-1-carboxylic acid tert-butyl ester (4.6 g crude, 8.97 mmol) afforded 5 g (100%) of the title compound as a crude residue, which was used without further purification.
出典と根拠
- ORDレコード
- ord-6a087676589342d1b5145c6164696bee
- 出典データセット
- uspto-grants-2008_09