Acetone → HCID 44444052、化合物
反応式
[CH3:1][C:2]1[C:10]2[C:5](=[CH:6][C:7]([C:11]([NH:13][C@H:14]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[CH2:15][O:16][CH2:17][CH:18]3[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]3)=[O:12])=[CH:8][CH:9]=2)[NH:4][CH:3]=1.[CH3:30][C:31]([CH3:33])=O>>[CH3:1][C:2]1[C:10]2[C:5](=[CH:6][C:7]([C:11]([NH:13][C@H:14]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[CH2:15][O:16][CH2:17][CH:18]3[CH2:19][CH2:20][N:21]([CH:31]([CH3:33])[CH3:30])[CH2:22][CH2:23]3)=[O:12])=[CH:8][CH:9]=2)[NH:4][CH:3]=1参加物
3
実験手順
Using alkylation method A, 3-methyl-N-[(R)-1-phenyl-2-(piperidin-4-ylmethoxy)ethyl]-1H-indole-6-carboxamide (400 mg, 1.0 mmol) and acetone (0.75 mL, 10 mmol) afforded, after purification (SiO2: 8:2:1 hexane:EtOAc:isopropylamine), 197 mg (44%) of the title compound.
後処理
- customafforded
- customafter purification (SiO2: 8:2:1 hexane:EtOAc:isopropylamine), 197 mg (44%) of the title compound
出典と根拠
- ORDレコード
- ord-ca6c2536d1ef48ff846d1b7a9b594ff9