関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 4-Methoxybenzenesulfonyl chloride | HCID 7401 | — |
| 反応物 | D-Aspartic Acid | HCID 83887 | — |
| 溶媒 | Sodium Hydroxide | HCID 14798 | — |
| 生成物 | L-Aspartic Acid | HCID 5960 | — |
反応手順
D-Aspartic acid (2.66 g) is suspended in 2N NaOH (30 mL) and 4-methoxyphenylsulfonyl chloride (4.12 g) is added. The mixture is stirred at 70° C. for 5 hours (clear solution), cooled down to room temperature and extracted with methylene chloride. The aqueous phase, after acidifying with 12N HCl, is extracted with ethyl acetate. The combined organic phases are with brine, dried (Na2SO4) and concentrated under reduced pressure to give N-[4-methoxyphenyl)sulfonyl]-D-aspartic acid as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06218389B1 |
|---|
| 出典データセット | uspto-grants-2001_04 |
|---|
| ORD ID | ord-de226369a28f4cc8b18b16c2cda762da |
|---|
| 出典メモ | uspto-grants-2001_04 |
|---|
