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4-(Hydroxyimino)-4-phenylbutanoic acid → 1-(4-Isopropylpiperazin-1-yl)-4-phenylbutane-1,4-dione 4-oxime
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-(Hydroxyimino)-4-phenylbutanoic acid | HCID 231936 | — |
| 反応物 | 1-Isopropylpiperazine dihydrochloride | HCID 12268378 | — |
| 生成物 | 1-(4-Isopropylpiperazin-1-yl)-4-phenylbutane-1,4-dione 4-oxime | HCID 86603602 | — |
反応手順
Using coupling method A, 4-hydroximino-4-phenylbutyric acid (500 mg, 2.6 mmol) and 1-isopropylpiperazine dihydrochloride (521 mg, 2.6 mmol) afforded, after purification (SiO2: 10% isopropylamine in EtOAc), 730 mg (89%) of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07427632B2 |
| 出典データセット | uspto-grants-2008_09 |
| ORD ID | ord-5ee8ce0057a141558d8a7a003d34a7f0 |
| 出典メモ | uspto-grants-2008_09 |