Hydrochloric Acid → 2-Amino-5-(4-methoxyphenyl)-3-furancarbonitrile

HRID 32467ノート

反応式

HRID 32467 の反応式
[CH3:1][O:2][C:3]1[CH:16]=[CH:15][C:6]([C:7]([CH2:9][CH:10]([C:13]#[N:14])[C:11]#[N:12])=[O:8])=[CH:5][CH:4]=1.Cl.O>C(O)(=O)C>[NH2:12][C:11]1[O:8][C:7]([C:6]2[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:16][CH:15]=2)=[CH:9][C:10]=1[C:13]#[N:14]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 153661992-(2-Oxo-2-(4-methoxyphenyl)ethyl)malononitrile

生成物 1

HCID 241067882-Amino-5-(4-methoxyphenyl)-3-furancarbonitrile収率 57.3%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

To a suspension of α-((4-methoxybenzoyl)methyl)malononitrile (9.66 g, 45.1 mmol) in acetic acid (50 ml) was added conc. hydrogen chloride (11,3 ml). The mixture was stirred at room temperature for 2 hours, and then poured into water. The resultant precipitation was filtrated, washed with water and ethanol, and dried under reduced pressure to give the Intermediate of Example 2(A) (5.54 g, 56%) as a solid. 1H NMR (400 MHz, CDCl3) ppm 3.83 (s, 3H), 4.74 (brs, 2H), 6.39 (s, 1H), 6.90 (m, 2H), 7.42 (m, 2H).

後処理

  1. customThe resultant precipitation
  2. filtrationwas filtrated
  3. washwashed with water and ethanol
  4. customdried under reduced pressure

出典と根拠

ORDレコード
ord-1996a01b8fb44706a2574631960b343b
出典データセット
uspto-grants-2008_09
特許番号
US07427623B2

反応ノート

読み込み中…