Phosphorus pentachloride → 4-Chloro-3-nitropyridine

HRID 324683

反応式

HRID 324683 の反応式
O[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[N+:8]([O-:10])=[O:9].P(Cl)(Cl)(Cl)(Cl)[Cl:12]>C(Cl)(Cl)Cl.C(O)C>[Cl:12][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[N+:8]([O-:10])=[O:9]

参加物

4

反応物 2

HCID 24819Phosphorus pentachlorideHCID 178526806HCID 178526806、化合物

生成物 1

HCID 27357814-Chloro-3-nitropyridine

試薬・触媒・溶媒 1

HCID 21889567Chloroform ethanol溶媒

実験手順

4-Chloro-3-nitropyridine was prepared from 4-hydroxy-3-nitropyridine(25 g, 0.179M), phosphorus pentachloride(40 g, 0.192M) and 1 mL of phosphorous oxytrichloride. The mixture was heated at 120° for 1 hour. The reaction mixture was diluted with chlorform/ethanol mixture(9/1) and the precipitate was filtered to afford desired. (mp. 153-154° C.)

後処理

  1. temperatureThe mixture was heated at 120° for 1 hour
  2. filtrationwas filtered
  3. customto afford

出典と根拠

ORDレコード
ord-6e835364453d44a4bcae929f8f059cf4
出典データセット
uspto-grants-2001_04
特許番号
US06218539B1

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