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4-(2-(Benzyl(methyl)amino)-1-hydroxyethyl)benzene-1,2-diol → (+-)-Adrenaline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-(2-(Benzyl(methyl)amino)-1-hydroxyethyl)benzene-1,2-diol | HCID 22005903 | — |
| 反応物 | HCID 178418361 | HCID 178418361 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Sulfuric Acid | HCID 1118 | — |
| 生成物 | (+-)-Adrenaline | HCID 838 | — |
反応手順
Benzyladrenaline 2 is dissolved in about 10 ml of water and about 5 ml of 18% sulfuric acid (pH: about 5.5), about 50 mg of palladium-charcoal (10%) are added and the mixture is hydrogenated at about 60° C. under 2 bar of hydrogen pressure. It is then evaporated down to about half its volume, about 20 ml of methanol are added and the mixture is cooled. The crystalline product (adrenaline sulphate 3) is filtered off and dried.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06218575B1 |
| 出典データセット | uspto-grants-2001_04 |
| ORD ID | ord-0d5d680909424c2b8d92acfc8a968ddf |
| 出典メモ | uspto-grants-2001_04 |