4-(2-(Benzyl(methyl)amino)-1-hydroxyethyl)benzene-1,2-diol → (+-)-Adrenaline

HRID 324713

反応式

HRID 324713 の反応式
[CH2:1]([N:8]([CH2:10][CH:11]([C:13]1[CH:20]=[CH:19][C:17]([OH:18])=[C:15]([OH:16])[CH:14]=1)[OH:12])C)C1C=CC=CC=1.[H][H]>O.S(=O)(=O)(O)O.[Pd]>[CH3:1][NH:8][CH2:10][CH:11]([C:13]1[CH:20]=[CH:19][C:17]([OH:18])=[C:15]([OH:16])[CH:14]=1)[OH:12]

参加物

6

反応物 2

HCID 220059034-(2-(Benzyl(methyl)amino)-1-hydroxyethyl)benzene-1,2-diolHCID 178418361HCID 178418361、化合物

生成物 1

HCID 838(+-)-Adrenaline

試薬・触媒・溶媒 3

HCID 23938Palladium触媒HCID 962Water溶媒HCID 1118Sulfuric Acid溶媒

実験手順

Benzyladrenaline 2 is dissolved in about 10 ml of water and about 5 ml of 18% sulfuric acid (pH: about 5.5), about 50 mg of palladium-charcoal (10%) are added and the mixture is hydrogenated at about 60° C. under 2 bar of hydrogen pressure. It is then evaporated down to about half its volume, about 20 ml of methanol are added and the mixture is cooled. The crystalline product (adrenaline sulphate 3) is filtered off and dried.

後処理

  1. customIt is then evaporated down to about half its volume, about 20 ml of methanol
  2. additionare added
  3. temperaturethe mixture is cooled
  4. filtrationThe crystalline product (adrenaline sulphate 3) is filtered off
  5. customdried

出典と根拠

ORDレコード
ord-0d5d680909424c2b8d92acfc8a968ddf
出典データセット
uspto-grants-2001_04
特許番号
US06218575B1

関連ノート

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