HCID 178474238、化合物 → HCID 178507147、化合物

HRID 32475

反応式

HRID 32475 の反応式
C([NH:4][C:5]1[CH:10]=[CH:9][C:8]([N:11]2[C:16]([NH2:17])=[C:15]3[CH:18]=[CH:19][O:20][C:14]3=[N:13][CH2:12]2)=[CH:7][CH:6]=1)(=O)C>[OH-].[K+].CCO.O>[NH2:17][C:16]1[N:11]([C:8]2[CH:7]=[CH:6][C:5]([NH2:4])=[CH:10][CH:9]=2)[CH2:12][N:13]=[C:14]2[O:20][CH:19]=[CH:18][C:15]=12

参加物

5

反応物 1

HCID 178474238HCID 178474238、化合物

生成物 1

HCID 178507147HCID 178507147、化合物収率 57.7%

試薬・触媒・溶媒 3

HCID 702Ethanol溶媒HCID 962Water溶媒HCID 14797Potassium Hydroxide溶媒

反応条件

温度
60 °C

実験手順

Compound 3-(4-acetamidophenyl)-4-aminofuro[2,3-d]pyrimidine 8 (242 mg) was dissolved in 2 M potassium hydroxide in the mixture of EtOH (16 mL) and water (4 mL). The mixture was heated (60° C.) for 24 h then concentrated in vacuo. Residual oil was triturated with cold water (6 mL) to give precipitation, which was filtrated, washed with water, and dried under the reduced pressure. The compound 9 (118 mg) as pale orange colored was obtained. MS(ES) m/e 227M+H].

後処理

  1. concentrationthen concentrated in vacuo
  2. customResidual oil was triturated with cold water (6 mL)
  3. customto give
  4. customprecipitation, which
  5. filtrationwas filtrated
  6. washwashed with water
  7. customdried under the reduced pressure

出典と根拠

ORDレコード
ord-f06b98cc45974b1297cfbef9da28bc0b
出典データセット
uspto-grants-2008_09
特許番号
US07427623B2

関連ノート

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