p-Tolunitrile → 4-Methylbenzene-1-carboximidamide hydrochloride
反応式
[C:1]1([CH3:9])[CH:6]=[CH:5][C:4]([C:7]#[N:8])=[CH:3][CH:2]=1.C[O-].[Na+].[Cl-:13].[NH4+:14]>CO>[ClH:13].[C:1]1([CH3:9])[CH:6]=[CH:5][C:4]([C:7]([NH2:14])=[NH:8])=[CH:3][CH:2]=1参加物
5
実験手順
To a solution of p-tolunitrile (10.0 g) in methanol (85 mlb) was added sodium methoxide (0.46 g) and the reaction was stirred at room temperature for 5 days. Ammonium chloride (4.6 g) was added and the reaction was stirred overnight. The reaction was filtered and the filtrate concentrated to an oil. After the addition of ether the off-white precipitate was collected and dried to give the title compound (4.52 g). Electrospray MS m/z 135 [M+H]+.
後処理
- stirringthe reaction was stirred overnight
- filtrationThe reaction was filtered
- concentrationthe filtrate concentrated to an oil
- additionAfter the addition of ether the off-white precipitate
- customwas collected
- customdried
出典と根拠
- ORDレコード
- ord-5aa06194480444fd8bcc6bf2fb801662
- 出典データセット
- uspto-grants-2001_04
- 特許番号
- US06218538B1
反応ノート
読み込み中…