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Triphenylphosphine → [2-(4-Cyanophenyl)ethoxy]-4-methyl-3-nitrobenzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triphenylphosphine | HCID 11776 | — |
| 反応物 | 3-Nitro-p-cresol | HCID 16271 | — |
| 反応物 | 4-(2-Hydroxyethyl)benzonitrile | HCID 2800815 | — |
| 反応物 | Diethyl azodicarboxylate | HCID 5462977 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | [2-(4-Cyanophenyl)ethoxy]-4-methyl-3-nitrobenzene | HCID 22033464 | — |
反応手順
4-Methyl-3-nitrophenol (0.765 g; 5.0 mmol), 2-(4-cyanophenyl)ethanol (0.735 g; 5.0 mmol) and diethylazodicarboxylate (0.87 g; 5.0 mmol) were dissolved in THF (20 mL). Triphenylphosphine (1.31 g; 5.0 mmol), dissolved in THF (5 mL), was added and the solution stirred overnight. Evaporation in vacuo and the addition of diethyl ether afforded a yellow solid that was recrystallized from water:acetone (9:1), affording the sub-title compound as yellowish crystals. Yield: 1.04 g (74%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06221898B1 |
| 出典データセット | uspto-grants-2001_04 |
| ORD ID | ord-d970b539f2dc42ef96a33271cf91092f |
| 出典メモ | uspto-grants-2001_04 |