1-(3-Chlorophenyl)cyclopropane-1-carbonyl chloride → N-[4-(4-amino-2H-furo[2,3-d]pyrimidin-3-yl)phenyl]-1-(3-chlorophenyl)cyclopropane-1-carboxamide

HRID 32504

反応式

HRID 32504 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2([C:11](Cl)=[O:12])[CH2:10][CH2:9]2)[CH:5]=[CH:6][CH:7]=1.[NH2:14][C:15]1[N:20]([C:21]2[CH:26]=[CH:25][C:24]([NH2:27])=[CH:23][CH:22]=2)[CH2:19][N:18]=[C:17]2[O:28][CH:29]=[CH:30][C:16]=12>>[NH2:14][C:15]1[N:20]([C:21]2[CH:22]=[CH:23][C:24]([NH:27][C:11]([C:8]3([C:4]4[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=4)[CH2:10][CH2:9]3)=[O:12])=[CH:25][CH:26]=2)[CH2:19][N:18]=[C:17]2[O:28][CH:29]=[CH:30][C:16]=12

参加物

3

反応物 2

HCID 242740301-(3-Chlorophenyl)cyclopropane-1-carbonyl chlorideHCID 178507147HCID 178507147、化合物

生成物 1

HCID 178507150N-[4-(4-amino-2H-furo[2,3-d]pyrimidin-3-yl)phenyl]-1-(3-chlorophenyl)cyclopropane-1-carboxamide

実験手順

The compound was prepared following the procedure described in Example 474, using 1-(3-chloro-phenyl)-cyclopropanecarbonyl chloride as the acid chloride of choice, and 4-Amino-3-(4-aminophenyl)furo[2,3-d]pyrimidine (9) as the diamine of choice. MS(ES) m/e 405 [M+H]+.

後処理

  1. customThe compound was prepared

出典と根拠

ORDレコード
ord-c025bb2240e346f0acc5227c52ec6b61
出典データセット
uspto-grants-2008_09
特許番号
US07427623B2

関連ノート

読み込み中…