Benzyl Bromide → HCID 178418227、化合物

HRID 3251

反応式

HRID 3251 の反応式
[CH2:1](Br)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:9][C:10]1([CH3:17])[NH:14][C:13](=[S:15])[NH:12][C:11]1=[S:16]>C(O)C>[CH2:1]([S:15][C:13]1[NH:14][C:10]([CH3:17])([CH3:9])[C:11](=[S:16])[N:12]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 7498Benzyl BromideHCID 30021425,5-Dimethyl-2,4-imidazolidinedithione

生成物 1

HCID 178418227HCID 178418227、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Initially, 1.91 mL of benzylbromide was added to a solution of 1.6 g of 5,5-dimethyl-2,4-dithiohydantoin in 50 mL of ethanol (EtOH). The reaction mixture was stirred at the room temperature for one hour, and concentrated in vacuo. The residue was treated following the procedure used in Example 62, and purified by column chromatography (CHCl3). Recrystallization from diethyl ether-n-hexane gave 2-benzylthio-5,5-dimethylimidazolin-4-thione in the form of a needle-like crystal. The yield of this compound was 0.87 g with a yield ratio of 34.8%, and the melting point was 133°-134° C.

後処理

  1. concentrationconcentrated in vacuo
  2. additionThe residue was treated
  3. custompurified by column chromatography (CHCl3)
  4. customRecrystallization from diethyl ether-n-hexane

出典と根拠

ORDレコード
ord-2f49fa4e191649188ac77496c1af416a
出典データセット
uspto-grants-1998_03
特許番号
US05733922

関連ノート

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