Hydrochloric Acid → N-(4-Formyl-2-pyrimidinyl)acetamide

HRID 325113ノート

反応式

HRID 325113 の反応式
C[O-].[Na+].C(O[O:8][CH:9](OC)[C:10]1[CH:15]=[CH:14][N:13]=[C:12]([NH:16][C:17](=[O:19])[CH3:18])[N:11]=1)(=O)C.Cl>CO>[C:17]([NH:16][C:12]1[N:11]=[C:10]([CH:9]=[O:8])[CH:15]=[CH:14][N:13]=1)(=[O:19])[CH3:18]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 10942334Sodium MethoxideHCID 22002535HCID 22002535、化合物

生成物 1

HCID 17840022N-(4-Formyl-2-pyrimidinyl)acetamide

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Sodium methoxide (0.056 g, 1.0 mmol) was added to a solution of 2-acetamidopyrimidine-4-carboxaldehyde monomethyl monoacetoxy acetal (5.0 g, 21 mmol) in MeOH (25 mL) at ambient temperature. After stirring at this temperature for 3 h, the reaction mixture was neutralized by addition of 3N HCl. The resulting solution was concentrated and the residue was treated with CH2Cl2. Remaining solids were removed by filtration and the solvent was evaporated to afford the title compound as a yellow solid; yield 3.2 g (92%).

後処理

  1. concentrationThe resulting solution was concentrated
  2. additionthe residue was treated with CH2Cl2
  3. customwere removed by filtration
  4. customthe solvent was evaporated

出典と根拠

ORDレコード
ord-c2add1b08275486fb8df1c945bdbc93b
出典データセット
uspto-grants-2001_04
特許番号
US06222036B1

反応ノート

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