Methanol → Methyl 2-chloromethylbenzoate
反応式
[Cl:1][CH2:2][C:3]1[CH:11]=[CH:10][CH:9]=[CH:8][C:4]=1[C:5](Cl)=[O:6].[CH3:12][OH:13]>>[CH3:12][O:13][C:5](=[O:6])[C:4]1[CH:8]=[CH:9][CH:10]=[CH:11][C:3]=1[CH2:2][Cl:1]参加物
3
実験手順
180 g of o-(chloromethyl)benzoyl chloride was placed in a double-neck 500 ml flask equipped with a thermometer, cooler and dropping funnel. While maintaining the internal temperature of a reactor at 40˜50° C., 50 ml of methanol was added dropwise. After all amounts of methanol were infused, the reacting mixture was stirred for 10 hours, while maintaining the internal temperature of a reactor at 40˜50° C. After a distillator was equipped, a fractional distillation under reduced pressure was made to afford 165 g of desired compound (yield 94%) as oil.
後処理
- customequipped with a thermometer, cooler
- temperatureWhile maintaining the internal temperature of a reactor at 40˜50° C.
- temperaturewhile maintaining the internal temperature of a reactor at 40˜50° C
- customAfter a distillator was equipped
- distillationa fractional distillation under reduced pressure
出典と根拠
- ORDレコード
- ord-51dd94455e294b879d4849a7b0044ceb
- 出典データセット
- uspto-grants-2001_04
- 特許番号
- US06222060B1
反応ノート
読み込み中…