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Methyl phenyl sulfoxide → Fluoromethyl phenyl sulfide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl phenyl sulfoxide | HCID 14516 | — |
| 反応物 | (Bis(2-methoxyethyl)amino)sulfur trifluoride | HCID 2734690 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | Fluoromethyl phenyl sulfide | HCID 5314298 | 70% |
反応手順
A solution of methyl phenyl sulfoxide (140 mg, 1 mmol) in CH2Cl2 (5.0 mL) was added to bis(methoxyethyl)aminosulfur trifluoride (332 mg, 1.5 mmol ) under N2 and stirred for 16 h at room temperature. After work-up as above fluoromethyl phenyl sulfide (70% yield as determined by NMR) was obtained. 1H NMR (CDCl3) d 7.5-7.0 (m, 5H), 3.3 (d, 2H). 19F
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06222064B1 |
| 出典データセット | uspto-grants-2001_04 |
| ORD ID | ord-4673f1042265459c9d785ad4c610d1f1 |
| 出典メモ | uspto-grants-2001_04 |