4-tert-Butylcyclohexanone → 4-Tert-butyl-1,1-difluorocyclohexane
反応式
[C:1]([CH:5]1CCC(=O)CC1)(C)([CH3:3])[CH3:2].C(N(S(F)(F)[F:18])CC)C.[F:21][C:22]1[CH:27]=[CH:26][C:25](OC)=[CH:24][CH:23]=1>C(Cl)Cl>[F:21][C:22]1([F:18])[CH2:27][CH2:26][CH:25]([C:1]([CH3:5])([CH3:3])[CH3:2])[CH2:24][CH2:23]1参加物
5
実験手順
A reaction of 4-t-butylcyclohexanone (2 mmol) with diethylaminosulfur trifluoride (3.0 mmol) in CH2Cl2 (10 mL) at room temperature gave a 99% conversion of starting material to products and a 67% yield of 1,1-difluoro-4-t-butylcyclohexane after 6 h. as determined by NMR (4-fluoroanisole as internal standard).
後処理
- customgave a 99% conversion of starting material to products
出典と根拠
- ORDレコード
- ord-78b0529538344dfea03417bf3a6c2e66
- 出典データセット
- uspto-grants-2001_04
- 特許番号
- US06222064B1
反応ノート
読み込み中…