1,7-Heptanediamine → HCID 178433306、化合物

HRID 325302

反応式

HRID 325302 の反応式
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][NH2:9].[C:10]([NH:12][C:13](=[N:16][CH2:17][CH2:18][S:19][CH2:20][C:21]1[NH:25][CH:24]=[N:23][C:22]=1[CH3:26])SC)#[N:11]>>[C:10]([NH:12][C:13]([NH:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][NH2:9])=[N:16][CH2:17][CH2:18][S:19][CH2:20][C:21]1[NH:25][CH:24]=[N:23][C:22]=1[CH3:26])#[N:11]

参加物

3

反応物 2

HCID 695331,7-HeptanediamineHCID 178503877HCID 178503877、化合物

生成物 1

HCID 178433306HCID 178433306、化合物収率 30.8%

実験手順

1,7-Diaminoheptane (5.2 g) was warmed gently until molten and to it was added N-cyano-N'-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]-S-methylisothiourea (2.69 g). After stirring for 15 hours at room temperature the reaction mixture was extracted with ether to remove excess of the diamine starting material and then purified on a silica gel chromatographic column, eluting with isopropanol to give the title compound (1.08 g), m.p. 84°-87° C.

後処理

  1. extractionwas extracted with ether
  2. customto remove excess of the diamine starting material
  3. custompurified on a silica gel chromatographic column
  4. washeluting with isopropanol

出典と根拠

ORDレコード
ord-2ad1f7e4c50d4181ba412e1b1e311d17
出典データセット
uspto-grants-1984_04
特許番号
US04440775

関連ノート

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