化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → 2-Amino-3-(trifluoromethyl)benzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Hydrogen Peroxide | HCID 784 | — |
| 反応物 | 7-Trifluoromethylisatin | HCID 604575 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Sodium Hydroxide | HCID 14798 | — |
| 生成物 | 2-Amino-3-(trifluoromethyl)benzoic acid | HCID 604569 | — |
反応手順
7-Trifluoromethylisatin (10 g, 46 mmol) was dissolved in 5% sodium hydroxide solution (83 ml). To this was added dropwise over 30 minutes a solution of 50% hydrogen peroxide (7.4 ml) in water (4.6 ml); the temperature rose to 50°. The solution was stirred an additional 30 minutes, acidified (conc. HCl) to pH 1-2, and the tan product was filtered.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04440941 |
| 出典データセット | uspto-grants-1984_04 |
| ORD ID | ord-c4d53f54931b4664aa89f8d725f00624 |
| 出典メモ | uspto-grants-1984_04 |