Tert-butyl 2-(cyclopentylamino)acetate → N-(2-Acetylthio-3-methylbenzoyl)-N-cyclopentylglycine t-butyl ester

HRID 325489ノート

反応式

HRID 325489 の反応式
[C:1]([O:5][C:6](=[O:14])[CH2:7][NH:8][CH:9]1[CH2:13][CH2:12][CH2:11][CH2:10]1)([CH3:4])([CH3:3])[CH3:2].[C:15]([S:18][C:19]1[C:27]([CH3:28])=[CH:26][CH:25]=[CH:24][C:20]=1[C:21](O)=[O:22])(=[O:17])[CH3:16]>C(Cl)Cl>[C:1]([O:5][C:6](=[O:14])[CH2:7][N:8]([C:21](=[O:22])[C:20]1[CH:24]=[CH:25][CH:26]=[C:27]([CH3:28])[C:19]=1[S:18][C:15](=[O:17])[CH3:16])[CH:9]1[CH2:10][CH2:11][CH2:12][CH2:13]1)([CH3:4])([CH3:2])[CH3:3]

参加物

4

反応物 2

HCID 13298943Tert-butyl 2-(cyclopentylamino)acetateHCID 204652132-Acetylthio-3-methylbenzoic acid

生成物 1

HCID 20465218N-(2-Acetylthio-3-methylbenzoyl)-N-cyclopentylglycine t-butyl ester

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

反応条件

温度
0 °C

実験手順

N-Cyclopentylglycine t-butyl ester (8.3 g, 0.042 mole) and 2-acetylthio-3-methylbenzoic acid (8.9 g, 0.042 mole) were combined in 90 ml CH2Cl2. This solution was cooled to 0° C. before adding to it a solution of N,N-dicyclohexylcarbodiimide (8.6 g, 0.042 mole) in 30 ml CH2Cl2 dropwise over 15 minutes. The reaction was allowed to warm slowly to room temperature overnight.

後処理

  1. temperatureto warm slowly to room temperature overnight

出典と根拠

ORDレコード
ord-55004cc9fd5d472c8dbaa8bd9cb6e1a1
出典データセット
uspto-grants-1984_04
特許番号
US04440941

反応ノート

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