Dichloromethane → 9-Octadecen-1-ol, methanesulfonate, (9Z)-

HRID 325547

反応式

HRID 325547 の反応式
ClCCl.[OH:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH:13]=[CH:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22].[CH3:23][S:24](Cl)(=[O:26])=[O:25]>C(N(CC)CC)C>[CH3:23][S:24]([O:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH:13]=[CH:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])(=[O:26])=[O:25]

参加物

5

反応物 3

HCID 6344DichloromethaneHCID 89279-Octadecen-1-olHCID 31297Methanesulfonyl chloride

生成物 1

HCID 1188619-Octadecen-1-ol, methanesulfonate, (9Z)-

試薬・触媒・溶媒 1

HCID 8471Triethylamine溶媒

実験手順

To a mixture of 250 ml. of dichloromethane, 25 g. 1-hydroxyoctadec-9-ene and 16.7 g. of triethylamine cooled in an ice-salt bath to -10° C. is added dropwise, over 15 minutes, 18.9 g. of methanesulfonyl chloride. The mixture is cooled at -10° C. to -15° C. for 30 minutes and then washed with 300 ml. each of cold water, 10% hydrochloric acid, sodium carbonate solution and with saturated sodium chloride solution. The organic layer is dried with magnesium sulfate and concentrated in vacuo to give a pale yellow oil.

後処理

  1. additionTo a mixture of 250 ml
  2. additionis added dropwise, over 15 minutes
  3. temperatureThe mixture is cooled at -10° C. to -15° C. for 30 minutes
  4. washwashed with 300 ml
  5. dry with materialThe organic layer is dried with magnesium sulfate
  6. concentrationconcentrated in vacuo
  7. customto give a pale yellow oil

出典と根拠

ORDレコード
ord-409d0ed842dd4db8bbd0cbb1b69dc27f
出典データセット
uspto-grants-1984_04
特許番号
US04440940

関連ノート

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