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Hydrazine hydrate (1:1) → 4-[3-Aminopropoxy]-N,N-dimethylbenzeneethanamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrazine hydrate (1:1) | HCID 24654 | — |
| 反応物 | 2-[3-[4-[2-(Dimethylamino)ethyl]phenoxy]propyl]-1H-isoindole-1,3-(2H)-dione | HCID 21297567 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 4-[3-Aminopropoxy]-N,N-dimethylbenzeneethanamine | HCID 21297555 | — |
反応手順
2-[3-[4-[2-(Dimethylamino)ethyl]phenoxy]propyl]-1H-isoindole-1,3-(2H)-dione (2.1 g) and hydrazine hydrate (1.2 ml) were heated at reflux in ethanol for 4 h. The solvent was evaporated and the residue was distilled to give the title compound as a clear yellow oil b.p. 170° (0.1 mm). TLC silica; ethyl acetate:water:isopropanol:0.88 ammonia 25:8:15:2; Rf 0.35.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04442110 |
| 出典データセット | uspto-grants-1984_04 |
| ORD ID | ord-a7dd293f0c334bf2a6bbdb2de53afc76 |
| 出典メモ | uspto-grants-1984_04 |