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Propargyl bromide → 2-(Prop-2-yn-1-yloxy)benzene-1-sulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Propargyl bromide | HCID 7842 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2-Hydroxybenzene-1-sulfonamide | HCID 637546 | — |
| 溶媒 | Methyl Ethyl Ketone | HCID 6569 | — |
| 生成物 | 2-(Prop-2-yn-1-yloxy)benzene-1-sulfonamide | HCID 13472945 | — |
反応手順
A mixture of 35 g of 2-hydroxyphenylsulfonamide, 55.2 g of potassium carbonate, 15.5 ml of propargyl bromide and 1000 ml of ethyl methyl ketone is refluxed for 1.5 hours; it is then cooled, filtered, and concentrated by evaporation. The yield after recrystallisation of the residue from ethyl acetate is 30 g of 2-propargyloxyphenylsulfonamide, m.p. 143°-145° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04443243 |
| 出典データセット | uspto-grants-1984_04 |
| ORD ID | ord-47781081ac0a4e7d88cd65dc00613ba4 |
| 出典メモ | uspto-grants-1984_04 |